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[1] [5] Research into transdermal delivery of peptide medications faces significant challenges due to the large molecular size of GLP-1 analogs and the skin's natural barrier function

One of the significant challenges can be proving clinical effectiveness in humans by relying on in vitro data and animal model data, which may not always accurately mirror human disease progression and pharmacological response mechanisms

Nasal delivery of GLP-1 RA has the potential to suppress appetite ignited in the olfactory bulb, which is distinct from the regular systemic administration mechanism

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