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Poe and Corn, 2020

11,12 Mice lacking IGF-1R specifically in chondrocytes exhibit a shorter and narrower growth plate, and the size of individual hypertrophic chondrocytes appeared smaller compared to that of control littermates

Repeated injection into the same site causes tissue damage and reduced absorption Bloodwork: If running any GH-axis compound for more than 8 weeks, get IGF-1 tested at baseline and at 6-8 weeks Source quality: Every benefit described in every article on this site is contingent on compound purity

Common starting age While there is no universally agreed-upon age, treatment often begins in middle age, when GH levels noticeably decline