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Many factors can contribute to confusion: NAION often occurs without headache, pain, or redness No other symptoms may be present aside from vision loss Patients may dismiss changes as part of aging, eye strain, or diabetes itself Symptoms usually appear suddenly upon waking, causing surprise rather than suspicion Without clear warning signs, people may delay seeking medical or legal help, assuming the issue is unrelated or temporary

Untreated endocrine disorders including hypothyroidism and uncontrolled diabetes require correction before initiating either compound

Most patients reach therapeutic doses between weeks 8 and 16 of treatment

Spinal cord demyelination associated with biotinidase deficiency in 3 Chinese patients