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When GLP-1 signaling increases, it can temporarily shift neurotransmitter balance, affecting both rapid eye movement (REM) sleep and deep sleep stages

Retatrutide is different because it targets three of these hormones at the same time

More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1." Confirming the Findings in Humans and Mice Because the results were unexpected, the researchers spent several years verifying them through multiple approaches