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(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)

NSAIDs like ibuprofen (400-600mg every 6-8 hours) provide first-line pain relief and can reduce menstrual flow by up to 25% when started 1-2 days before periods

But the side effect profile that comes with finasteride is also in a different category, and for a significant number of people, hormonal intervention isn't an option or isn't something they want