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While the mechanistic framework presented here aligns with established GLP-1R signaling and trafficking paradigms, the proposed Ca 2+ cAMP disruption and -arrestinmediated adaptation in salivary acinar cells should be considered hypothesis-generating, as direct salivary-tissue evidence under semaglutide exposure is currently lacking

Though the absolute risk of GLP-1 related aspiration during intubation is still low, case studies of large volume emesis in patients who fasted 20 hours have been concerning enough to prompt the American Society of Anesthesiology to issue a guidance suggesting holding GLP-1 agonists prior to elective intubations4,5

You should seek immediate medical attention for symptoms like severe abdominal pain that radiates to your back, persistent vomiting, or signs of an allergic reaction like hives or difficulty breathing