In the only direct evaluation of brain insulin resistance in PD, insulin signaling abnormalities were identified in the dorsolateral prefrontal and posterior parietal cortex of those with cognitive impairment, but not in those who were cognitively normal [72]
It is well established that better mental health tends to follow from better physical health and since the 1880s we have known that diabetes is associated with depression, although I think its unlikely that using GLP-1R agonists alone as treatments for depression or anxiety will work, said Prof David Nutt, according to The Guardian.
The dual GLP-1/GIP receptor agonist DA4-JC shows superior protective properties compared to the GLP-1 analogue Liraglutide in the APP/PS1 mouse model of Alzheimers disease
Resumiendo, Mounjaro (Tirzepatida), combina las dos incretinas el GLP-1 y el GIP , las dos hormonas retrasan el vaciamiento gstrico y a nivel del cerebro aumentan la saciedad, disminuyendo la ingesta de alimentos, reduciendo la sensacin de hambre que finalmente lleva a una disminucin de peso principalmente por una disminucin de la masa grasa.
