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This oxidative stress can activate classical apoptotic pathways, a process termed copper-induced apoptosis, which is mediated by DNA/membrane damage and the caspase/Bcl-2/p53 pathway and can be inhibited by caspase inhibitors [7]

As mentioned above, IFN--2b (both high and low dose) is subject to intensive investigation

The headache phase follows the prodromal or aura stages of a migraine, marked by the activation and sensitization of the trigeminovascular system (TVS) and brainstem, leading to disrupted sensory processing and various neurological symptoms indicative of altered brain excitability (29)

This correlation implies that ADAs may exacerbate immune responses, further stimulating complement activation