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These mucosal regenerative effects have been consistently demonstrated in experimental animal models of IBD (87), complementing their currently approved use of GLP-2 analogs in short bowel syndrome (88, 89)

These studies have been enabled by the discovery of novel small molecules, including Fer-1 [5], improved Fer-1 analogs [7, 8] and liproxstatin-1 [9], that potently and specifically block ferroptosis

10.1007/164_2020_406 99 LudlowM.KortekaasJ.HerdenC.HoffmannB.TappeD.TrebstC.et al