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Transcription factor Nrf2 is a major transactivator of cytoprotective genes in response to oxidative stress and xenobiotic electrophiles

Nonetheless, existing NADPH sensors face major limitations, including sensitivity to pH, a lack of responsiveness to NADP + , a low signal-to-noise ratio, and a lack of compatibility with alternative measurement techniques like FLIM

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It earns this title because it does something most other nutrients cannot: it recycles itself