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In fact, MS was one of the first CNS diseases where gut bacteria were shown to have a causal influence in animal models: in 2011, it was demonstrated that segmented filamentous bacteria in the gut could trigger CNS-autoreactive Th17 cells and provoke an MS-like disease in mice [181]

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whether it offers any advantage for Ipamorelin specifically has not been established in human trials, so it is presented as a documented option, not a proven-superior method

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