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One of the catalysts was his participation in the Second International Bacteriophage Colloquium organised at Abbaye de Royaumont near Paris by Andr Lwoff and Franois Jacob, two French biologists

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6 They activate mitogen-activated protein kinase (MAPK) pathways that induce key regulators in late G1 phase such as Cyclin Ds and cyclin-dependent-kinases 4/6 (CDKs), which have a critical role in the control of the G1/S transition and the commitment to DNA replication