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A major breakthrough in 2023 was the introduction of glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist tirzepatide, which activates both receptors and has shown superior glucose-lowering and weight-reducing effects in both clinical trials and real-world Japanese settings
The therapeutic potential of a venomous lizard: The use of glucagon-like peptide-1 analogues in the critically ill
Indeed, the administration of oxyntomodulin reduces food intake and suppresses appetite [41] by activation of GLP-1 receptors [42] and increases energy expenditure via activation of the glucagon receptor [43]
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