The quality of imputation was assessed through density plots comparing original and imputed distributions for each variable within each brain region, ensuring the preservation of the original data structure ( Supplementary Fig
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When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation
Although a basal level of radical production is important for proper physiological function [5], overexpression of radical species, either via increased production or decreased antioxidant defense, can result in oxidative damage to lipids, proteins, and nucleic acids, all of which may contribute to the pathophysiology of disease [6]
