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People with HIV often experience accelerated biological aging, even when their virus is well controlled with medication

For instance, studies have reported average weight losses ranging from 2% to 4% of baseline body weight over a span of 12 to 24 weeks

These reports show that a high-fat diet (HFD) decreases PHLPP-2 stability, which delayed Akt dephosphorylation and then induces prolonged Akt activation in late stage after insulin pulse [43,44]

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