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Orlistat and cyclosporine should not be simultaneously co-administered Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because Orlistat has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene Rare cases of severe liver injury with hepatocellular necrosis or acute hepatic failure have been reported, with some of these cases resulting in liver transplant or death Patients may develop increased levels of urinary oxalate following treatment with Orlistat
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Therefore, our data indicated that the upregulation of GSTA2 provides protective advantages for HCCs against high ROS-induced damage during the early phase after LT and subsequently increases the likelihood of HCC recurrence
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