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B2M is a low molecular-weight protein filtered completely and almost completely reabsorbed by the proximal tubule

5 Conclusion In conclusion, we report a novel glutathione-responsive nanoplatform that integrates three complementary functional componentsSBA-15 mesoporous silica as a high-capacity carrier, enzalutamide covalently tethered to the silica via redox-sensitive disulfide linkages, and thiolated nitrogen-doped carbon dots (SNCDs) as stable fluorescent reporterstogether with folic-acid surface decoration for active tumor targeting

Creates a more favorable environment for new growth

This vascular limitation explains why conventional treatments often fall short