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Those prescribed non-GLP-1 diabetes medications (e.g., insulin, metformin)

Its selective action, without raising cortisol or prolactin levels, makes it a focus in research requiring stable hormonal response

Statistical Design The study was designed to detect a difference of 0.5 standard deviation (SD) in the change (baseline to week 4) of average fatigue between the two arms, with 85% power, assuming an intrapatient correlation of 0.5, using a Wilcoxon-Mann-Whitney test with a two-sided type I error of 5%