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The key publications that established its pharmacological profile include: Study Year Journal Key Finding Raun et al

We do not prescribe GH-releasing peptides to patients whose IGF-1 is already in the high-normal range for their age, because stimulating further GH elevation in that context produces diminishing returns and increases the theoretical risk of side effects from GH excess

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These mechanisms mirror those of other IGF-1 forms but occur with higher local intensity due to IGF-1 DES's enhanced potency