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Subsequent progenies were generated by mating Gipr fl/fl male mice (no synapsin-Cre) with female homozygous floxed Gipr mice with the synapsin-Cre transgene ( Gipr Syn/ ) to produce mice with CNS KO of Gipr ( Gipr Syn/ )

Instead, only activation of Oxtr -containing neurons, exclusively intestinal IGLEs that detect stretch, potently suppressed food intake, while various subtypes of mucosal ending neurons, which are classically thought to sense gut peptides, had no effect 28

However, the conventional forms face limitations in bioavailability and targeted delivery, which can be overcome using nanotechnology-based formulations such as niosomes 19,20