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Beyond determining your physique, your metabolism is also responsible for converting food into energy by oxidizing nutrients and breaking them down

That excess insulin triggers a cascade: the ovaries are overstimulated to produce androgens, the hypothalamic-pituitary axis loses its normal rhythm, and ovulation becomes irregular or absent

Given that portal delivery of insulin, which has the potential to completely restore IGF-I levels in type 1 diabetes (70, 71, 87), remains an experimental treatment, rhIGF-1 treatment to restore circulating IGF-I and suppress GH and decrease insulin needs appears to be the most feasible approach to take (88)

Medical experts can then evaluate whether the available evidence collectively supports a causal relationship