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Several human studies have proven that the actions of GLP-1R agonists in the brain are regulated by sensory and cognitive factors

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Both semaglutide (brand names Ozempic, Wegovy) and tirzepatide (Mounjaro) are glucagon-like peptide-1 (GLP-1) receptor agonists that work by mimicking a hormone to reduce appetite, however tirzepatide uniquely also activates the glucose-dependent insulinotropic polypeptide (GIP) receptor unlike semaglutide which only activates the GLP-1 receptor