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Causes of Low Glutathione Levels Several factors can deplete glutathione in the body

CAFs, in particular, are vital contributors to ECM remodeling, secreting collagen I and fibronectin that increase ECM stiffness and activate tumor-promoting signaling pathways, including the YAP/TAZ pathway

Detoxifies the liver: The liver relies on glutathione to convert toxins into water-soluble substances that can be safely eliminated from the body

Several studies in noise-exposed rats, chinchillas, and rabbits, have reported that the administration of NAC minimizes the progression of apoptosis in sensory hair cells and reduces significantly the auditory threshold shifts, at low and medium frequencies, as compared to untreated animals (Kopke et al., 2000