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Pre-treatment of the cells with 1.5 mM of quercetin significantly reduced the expression of AD-induced IL-1b, IL-6, IL-8, and thymic stromal lymphopoietin (TSLP), while it strongly enhanced the expression of superoxide dismutase-1 (SOD1), SOD2, catalase, glutathione peroxidase, and IL-10 [53]

In addition, we found that NAC treatment prevented THC-induced increases in the polyamine spermidine, which is known to regulate glutamatergic signaling by potentiating NMDA-receptor sensitivity to glycine [105]

One reason is coverage and access has expanded, especially for pre-existing type 2 diabetes

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