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Eye Changes (Graves Ophthalmopathy): Bulging eyes (exophthalmos): The eyes may appear to protrude or bulge

PLC-2 then competes with PI-3K for PIP 2 which it hydrolyzes into IP 3 (inositol 1,4,5-trisphosphate), which ultimately raises intercellular calcium, and diacylglycerol (DAG), which activates portions of the PKC family

For PGA, concentrations were calculated from the ratio of endogenous metabolite to isotopically labelled internal standards, compared against calibration curves of increasing endogenous standard concentrations