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systematically reviewed the oxidative stress from the perspectives of oxidants and antioxidants, and noted that oxidants with vastly different half-lives may be observed at the site of generation or be transported to distant target sites where they exert oxidant activities in cell metabolism [63]

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Since acidosis is a hallmark of inflammatory processes as well as a crucial determinant of tumor progression, resulting from the increased glycolysis and the subsequent accumulation of lactic acid as well as the massive production of protons [83], glutamine supplementation may help to reduce inflammation in cancer cachexia patients by maintaining pH homeostasis in the body via ammonia (NH 3 ) transport between tissues [5,84]

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