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The British Journal of Dermatology

Behind this surge in deals, multinational companies (MNCs) are still heavily investing, but their focus has subtly shifted: On one hand, the extended development around the GLP-1R target has become mainstream, with synergistic targets such as amylin becoming breakthroughs for enhanced efficacy

The FDA approved Zepbound for people with obesity and those who are overweight and have at least one health condition linked to their weight, such as high blood pressure, Type 2 diabetes or high cholesterol, according to an FDA press release

External appeals have a higher overturn rate, particularly when clinical justification beyond BMI alone is strong (cardiovascular indication, sleep apnea documented by sleep study, or other comorbidities)