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doi: 10.1016/j.molmet.2023.101805 17 WangYDilidaxiDWuYSailikeJSunXNabiXH

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[19] [20] Key factors influencing emotional responses include: Baseline testosterone levels Men with clinically low testosterone often experience mood improvements when levels normalise Dosing regimen The method of administration (injections, gels) affects how steadily testosterone levels remain, with more stable levels generally associated with fewer mood fluctuations Individual sensitivity Genetic variations in androgen receptor expression and enzyme activity (such as aromatase, which converts testosterone to oestradiol) create person-specific responses [3] [4] Pre-existing mental health conditions Those with underlying mood disorders may experience different effects compared to individuals without such histories Whilst testosterone therapy is generally well-tolerated when appropriately prescribed and monitored, mood changes including irritability, aggression, and mood swings are recognised potential side effects listed in product information