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If the serum also contains vitamin C, niacinamide, tranexamic acid, or alpha-arbutin, it may make more sense for someone looking to target dark spots and dull skin

Additionally, stress-inducing agents such as tunicamycin, thapsigargin and histidinol have been shown to modulate CHAC1 regulation, indicating its involvement not only during ER stress but also in the context of the ISR ( CHAC1 promoter is the primary mechanism for the transcriptional upregulation of the gene

Third, the safety profile in trials has been clean, with no reported adverse effects

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