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On expression of the respective mRNA library using the ClAc L Y or ClAc D Y initiator, linear peptides exceeding 10 12 unique members self-cyclized by reaction of the amino-terminal ClAc group and the sulfhydryl group of a downstream Cys residue to yield sulfide-macrocycles

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Copper peptides can soften deep wrinkles and improve surrounding skin quality but typically cannot completely eliminate established deep lines through topical use alone