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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

Springer Skipsey M, Davis BG, Edwards RD (2005) Diversification in substrate usage by glutathione synthetases from soya bean ( Glycine max ), wheat ( Triticum aestivum ) and maize ( Zea mays )

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Oxidative stress is a known factor in how the body manages airway sensitivity and inflammation