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Abstract Introduction: Endometriosis is a prevalent, estrogen-dependent, inflammatory disease that impairs fertility via hormonal dysregulation, immune dysfunction, oxidative stress/ferroptosis, genetic and epigenetic alterations, and microbiome imbalance

Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis

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Ferroptosis targeting ameliorates experimental RRMS To target ferroptosis, we have previously shown the superior in vivo efficacy of our third-generation synthetic lipophilic radical trap compound UAMC-3203 in an experimental model for multi-organ failure [31]