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Kondisi ini bisa terjadi karena berbagai faktor, seperti jerawat, hormon, atau kerusakan kulit akibat paparan sinar matahari (melasma)

While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation

It can be speculated that the additional inflammatory burden caused by periodontal disease is not able to increase the already elevated inflammatory state caused by RA

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