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GPCRs transmit extracellular signals via coupling to heterotrimeric G proteins and interactions with -arrestins, leading to activation of various intracellular signalling cascades (15)

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According to the results of a national survey conducted in 2015, the annual rate of suicide attempts is three to five times greater in young adults aged 1825 years, compared with older age groups in the United States [Reference Piscopo, Cooney and Glasheen37]

(11) Studies have examined the compounds bioavailability following various routes of administration and its tissue distribution patterns