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These changes to normal gastrointestinal physiology explain why diarrhea (defined as three or more loose or watery stools per day) and other gastrointestinal symptomsincluding nausea, vomiting, constipation, and abdominal painare among the most frequently reported side effects

In the case of Wegovy, its because the use of semaglutide has been linked to a type of thyroid cancer in rodents, but this hasnt been reported in human trials

Semaglutide Therapy and Accelerated Sarcopenia in Older Adults With Type 2 Diabetes: A 24-Month Retrospective Cohort Study

This helps ensure the previous medicine has cleared from your system, reducing the risk of overlapping side effects and supporting a safe transition