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Key Characteristics: Blend Composition: Primarily Oriental tobacco, complemented by Virginia for added sweetness and depth

Chem Res Toxicol 15:677685 Prokopczyk B, Trushin N, Leszczynska J, Waggoner SE, El Bayoumy K (2001) Human cervical tissue metabolizes the tobacco-specific nitrosamine, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone, via alpha-hydroxylation and carbonyl reduction pathways

Pulmonary dendritic cells (DCs) are crucially involved in sensitization toward allergens and play an important role in the development of T helper (Th)2-mediated allergic airway inflammation

In 1894, they invented the process of "interleaving" rolling papers