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Many studies have demonstrated the efficacy of lifestyle intervention [31, 38, 39] and some drugs approved for the treatment of T2D (metformin, thiazolidinediones, and acarbose) and obesity (orlistat) [32, 40] in preventing or delaying the progression of prediabetes to T2D, showing clearly how weight loss is the main mediator of this effect [38, 41]

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