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Description

In a human CEP290 IVS26 knock-in mouse model, EDIT-101 had strong productive editing rates within photoreceptor cells, effectively restored normal splicing of the CEP290 mRNA, and restored the production of the full-length CEP290 protein [63]

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A side effect that occurs in 0.1% of patients (1 in 1,000) has only a 28% chance of appearing in a 338-person trial

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Thus, the main threat associated with severe HTG with fasting chylomicronaemia is acute pancreatitis (AP) [99, 213]

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Int J Mol Sci 23:449

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