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In line with these results, we detected lower CI activity in total lysates of Gclc -deficient FoB compared to control FoB (Fig

By activating the Nrf2 pathway, it disrupts iron accumulation, lipid peroxidation, and ferroptosis, preventing the downregulation of GSH and GPX4 levels, thus ameliorating cisplatin-induced AKI (183)

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Research mapping IGF-1 receptor binding describes IGF-1R activation after IGF-I and IGF-II binding, with signalling relevance in cell growth, survival and migration models