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PMID: 24802882 Nabatian-Asl M, Ghorbanihaghjo A, Malek Mahdavi A, Khabbazi A, Hajialilo M, Ghojazadeh M (2021) Effects of melatonin supplementation on serum oxidative stress markers and disease activity in systemic lupus erythematosus patients: A randomised, double-blind, placebo-controlled trial

Extensive clinical studies, including phases 1, 2, and 3, should be performed before the extract can be developed into an immunomodulatory agent to treat various immune-related disorders in clinical services

3.1.1 Enzyme-responsive nanomaterials Enzyme-responsive stimulus is an ideal choice for their application in biomedical field due to several advantages like high sensitivity and selectivity, catalytic efficacy, biorecognition, mild reaction conditions, and easy decomposition [49, 50]

It is also banned by WADA and USADA for all competitive athletes