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In conclusion, PCs can alleviate diabetes-induced myocardial hypertrophy, cardiac fibrosis, and heart failure, demonstrating potential cardioprotective effects by regulating the S100A11/RAGE/PPAR signaling pathway, improving mitochondrial function, reducing oxidative stress, and inhibiting the formation of AGEs

The chaperone BAG6 regulates cellular homeostasis between autophagy and apoptosis by holding LC3B

Fibrosis, overgrowth, sclerosis, and scarring of various tissues are attributed to the expansion of activated mesenchymal stromal cells (myofibroblasts), leading to excessive deposition of extracellular matrix components in basement membranes and interstitial tissues (Makena et al., 2023)