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The consistency of findings across multiple retrospective cohorts and data sources provides a compelling signal of efficacy on clinical endpoints, justifying a shift in research focus: the field now needs adequately powered phase 3 randomized controlled trials to validate these preliminary findings [58], define optimal treatment strategies such as dosing and treatment duration, and establish the role of GLP-1 RAs in both acute and long-term management of IIH

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To collect the cerebrospinal fluid (CSF), a small skin incision is made just posterior to the cranial vertex

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