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GLP-1 exerts its actions by binding to a G-protein coupled receptor (GLP-1R) expressed on the surface of many cells including -cells, which, upon stimulation, leads to rapid activation of adenylyl cyclase thus increasing cAMP levels 7

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Phosphatidylethanolamine-binding protein 1 (PEBP1) and arachidonate 15-lipoxygenase (ALOX15) can interfere with phospholipid alcohol synthesis and induce ferroptosis [5, 52]

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