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The aim to improve the effect of metformin led to the development of phenformin 43 , which showed an improved cellular uptake compared to metformin 44
DR stems from a complex pathology involving oxidative stress, inflammatory lesions, and the polyol pathway
Eggs, beef, fish, chicken and nuts represent dietary sources of choline (Derbyshire, 2019), individuals on a gluten-free or vegan restricted diet may also wish to consider pseudocereals amaranth, buckwheat and quinoa as alternative dietary sources for betaine (Ross et al, 2014)
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