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Extending the follow-up period to 5 or 10 years could provide a more comprehensive understanding of the long-term metabolic risks, as metabolic syndrome and its components, such as obesity and hypertension, often develop over an extended period

Effect of pulmonary damage on the pharmacokinetics of inhaled therapeutics In this section, we review how damaged respiratory tissue and disrupted pulmonary mechanisms affect the pharmacokinetics of inhaled drugs, notably, discussing the effects upon absorption, distribution, metabolism and elimination of prevalent medications such as beta agonists and inhaled corticosteroids