does chewing tobacco affect fatty liver Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Disease: Cellular and Mechanistic Insights Harmful Effects Of Tobacco Chewing

Nicotine when combined with a HFD, however, significantly increases the levels of serum, hepatic TG, and circulating FFA (42, 50)

The primary risk factors for NAFLD include obesity (particularly central adiposity), type 2 diabetes mellitus , insulin resistance , dyslipidaemia (abnormal cholesterol levels), and metabolic syndrome

J Hepatol (2009) 51:53547.10.1016/j.jhep.2009.03.026 41 AzzaliniLFerrerERamalhoLNMorenoMDominguezMColmeneroJet alCigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats

This direct exposure damages cells and increases the likelihood of mutations that can lead to cancer.The Nature Communications study highlighted that even moderate use of chewing tobacco over time can result in precancerous lesions and a faster progression to malignant tumors compared to cigarette smoking