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This increase in ECM proteins fibrosis separates the individual bundles of muscle cells and disturbs the impulse propagation that causes the heart to beat regularly.[ref] Animal studies from about a decade ago show a pressure overload in the heart (stressing out the heart) can cause mast cells to proliferate

Acknowledgements We thank Lauren Knightley, Beth Jago, Meirion Richards, and Amin Mirza of the Structural Chemistry team for their expertise and assistance, Swen Hoelder for his continuous support, Stephen Hearnshaw for his contributions to crystal optimisation, and Chris Richardson for crystallography computing support

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Glucagon-Like Peptide-1. PubChem , National Center for Biotechnology Information, National Library of Medicine, Mayer JP, et al