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In rodents, the 1.3 kb 5-flanking sequence is sufficient to direct transgene expression to Gcg + cells in the brain and the pancreas [95] but extension of this region to include 2.5 kb is required to target Gcg + cells in the intestine [96], including evolutionarily preserved sequences in the first intron [97]

Int J Dermatol 2006

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"Together, these results reinforce orforglipron's potential to become a new standard of care for people living with type 2 diabetes." Lilly has said it is preparing to file orforglipron for approval in obesity, likely before the end of the year, with a follow-up filing in type 2 diabetes anticipated in 2026