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This suggests it is cleared from the system quite rapidly, which has major implications for study design and dosing frequency

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Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

Kisspeptin is an endogenous peptide that stimulates gonadotropin-releasing hormone (GnRH) neurons, triggering luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release