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GDF15 levels have previously been stable over extended periods in chronic disorders, including chronic fatigue syndrome (ME/CFS), suggesting potential as a monitoring biomarker 35
Similarly, a recently approved antidiabetic agent of the same drug family, semaglutide, has been assessed in a double-blind phase 2 RCT in 320 patients with NASH without DM2, given subcutaneously once daily, at various doses, for 72 weeks (NCT02970942)
J Adv Res (2018) 13:517
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